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Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 1, doi: 10.1007/s11783-023-1604-5
● Metabolomic temporal profiling of cells exposed to xenobiotics.
Keywords: Metabolomics BPA MCF-7 Temporal profiling Metabolic adaption Dysregulation correlation
Exploring self-organization and self-adaption for smart manufacturing complex networks
Frontiers of Engineering Management 2023, Volume 10, Issue 2, Pages 206-222 doi: 10.1007/s42524-022-0225-1
Keywords: systems Industrial Internet of Things smart manufacturing complex networks self-organization and self-adaption
Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 8, doi: 10.1007/s11783-022-1527-6
• The promoting effects for VFA generation follow the order of APG>SDBS>HTAB.
Keywords: Waste activated sludge (WAS) Volatile fatty acids (VFA) Surfactant types Functional microorganisms Metabolic
Metabolic hypertension: concept and practice
Zhiming Zhu, Peijian Wang, Shuangtao Ma
Frontiers of Medicine 2013, Volume 7, Issue 2, Pages 201-206 doi: 10.1007/s11684-013-0264-4
Keywords: hypertension cardiometabolic risk factors metabolic abnormalities
Jianping Ye
Frontiers of Medicine 2015, Volume 9, Issue 2, Pages 139-145 doi: 10.1007/s11684-015-0377-z
In obesity, chronic inflammation is believed to induce insulin resistance and impairs adipose tissue function. Although this view is supported by a large body of literature, it has been challenged by growing evidence that pro-inflammatory cytokines may favor insulin sensitivity through induction of energy expenditure. In this review article, interleukin 15 (IL-15) is used as a new example to explain the beneficial effects of the pro-inflammatory cytokines. IL-15 is secreted by multiple types of cells including macrophages, neutrophils and skeletal muscle cells. IL-15 expression is induced in immune cells by endotoxin and in muscle cells by physical exercise. Its transcription is induced by transcription factor NF-κB. IL-15 binds to its receptor that contains three different subunits (α, β and γ) to activate JAK/STAT, PI3K/Akt, IKK/NF-κB and JNK/AP1 pathways in cells. In the regulation of metabolism, IL-15 reduces weight gain without inhibiting food intake in rodents. IL-15 suppresses lipogenesis, stimulates brown fat function, improves insulin sensitivity through weight loss and energy expenditure. In human, circulating IL-15 is negatively associated with body weight. In the immune system, IL-15 stimulates proliferation and differentiation of T cells, NK cells, monocytes and neutrophils. In the anti-obesity effects of IL-15, T cells and NK cells are not required, but leptin receptor is required. In summary, evidence from human and rodents supports that the pro-inflammatory cytokine IL-15 may enhance energy expenditure to protect the body from obesity and type 2 diabetes. The mechanism of IL-15 action remains to be fully uncovered in the regulation of energy expenditure.
Keywords: inflammation obesity cytokine energy expenditure insulin resistance
Frontiers of Medicine 2021, Volume 15, Issue 5, Pages 679-692 doi: 10.1007/s11684-021-0866-1
Keywords: metabolic reprogramming potential of electron transfer cell proliferation aerobic glycolysis cancer
Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology
Huating Li, Jing Zhang, Weiping Jia
Frontiers of Medicine 2013, Volume 7, Issue 1, Pages 25-30 doi: 10.1007/s11684-013-0244-8
Keywords: FGF21 metabolism pharmacology physiology clinical relevance
Metformin and metabolic diseases: a focus on hepatic aspects
Juan Zheng,Shih-Lung Woo,Xiang Hu,Rachel Botchlett,Lulu Chen,Yuqing Huo,Chaodong Wu
Frontiers of Medicine 2015, Volume 9, Issue 2, Pages 173-186 doi: 10.1007/s11684-015-0384-0
Metformin has been widely used as a first-line anti-diabetic medicine for the treatment of type 2 diabetes (T2D). As a drug that primarily targets the liver, metformin suppresses hepatic glucose production (HGP), serving as the main mechanism by which metformin improves hyperglycemia of T2D. Biochemically, metformin suppresses gluconeogenesis and stimulates glycolysis. Metformin also inhibits glycogenolysis, which is a pathway that critically contributes to elevated HGP. While generating beneficial effects on hyperglycemia, metformin also improves insulin resistance and corrects dyslipidemia in patients with T2D. These beneficial effects of metformin implicate a role for metformin in managing non-alcoholic fatty liver disease. As supported by the results from both human and animal studies, metformin improves hepatic steatosis and suppresses liver inflammation. Mechanistically, the beneficial effects of metformin on hepatic aspects are mediated through both adenosine monophosphate-activated protein kinase (AMPK)-dependent and AMPK-independent pathways. In addition, metformin is generally safe and may also benefit patients with other chronic liver diseases.
Keywords: metformin diabetes hepatic steatosis inflammatory response insulin resistance
Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 6, doi: 10.1007/s11783-021-1433-3
• Short-term effect of the pyridine exposure on the SAD process was investigated.
Keywords: Anammox Inhibition Metabolic pathway Microbial community Pyridine SAD
Water-dispersible nano-pollutions reshape microbial metabolism in type-specific manners: A metabolic
Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 9, doi: 10.1007/s11783-022-1548-1
• Water-dispersible nano-pollutions exhibit type-specific toxic effects on E. coli.
Keywords: Nano-toxicity Nano-plastics Quantum dots Microbial metabolite Metabolic dysregulation
Xiaokun Li
Frontiers of Medicine 2019, Volume 13, Issue 5, Pages 511-530 doi: 10.1007/s11684-019-0711-y
Keywords: FGF19 FGF21 FGF23 FGFR metabolism endocrine Klotho
Regulation of T cell immunity by cellular metabolism
Zhilin Hu, Qiang Zou, Bing Su
Frontiers of Medicine 2018, Volume 12, Issue 4, Pages 463-472 doi: 10.1007/s11684-018-0668-2
Keywords: T cell immunity metabolic pathways nutrient uptake metabolic checkpoints
Zinc homeostasis in the metabolic syndrome and diabetes
Xiao Miao, Weixia Sun, Yaowen Fu, Lining Miao, Lu Cai
Frontiers of Medicine 2013, Volume 7, Issue 1, Pages 31-52 doi: 10.1007/s11684-013-0251-9
Keywords: zinc zinc transporters metallothionein diabetes diabetic complications insulin resistance antioxidant
Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 3, doi: 10.1007/s11783-023-1637-9
● Converting xylose to caproate under a low temperature of 20 °C by MCF was verified.
Keywords: Xylose fermentation Caproate Low temperature Bifidobacterium FAB pathway RBO pathway
Metabolic flux analysis on arachidonic acid fermentation
JIN Mingjie, HUANG He, ZHANG Kun, YAN Jie, GAO Zhen
Frontiers of Chemical Science and Engineering 2007, Volume 1, Issue 4, Pages 421-426 doi: 10.1007/s11705-007-0077-6
Keywords: AA different fermentation concentration N-source exponential metabolic
Title Author Date Type Operation
Time-dependent metabolomics uncover dynamic metabolic adaptions in MCF-7 cells exposed to bisphenol A
Journal Article
Exploring self-organization and self-adaption for smart manufacturing complex networks
Journal Article
New insights into different surfactants’ impacts on sludge fermentation: Focusing on the particular metabolic
Journal Article
Metabolic hypertension: concept and practice
Zhiming Zhu, Peijian Wang, Shuangtao Ma
Journal Article
Beneficial metabolic activities of inflammatory cytokine interleukin 15 in obesity and type 2 diabetes
Jianping Ye
Journal Article
electron transfer and its application in dictating routes of biochemical processes associated with metabolic
Journal Article
Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology
Huating Li, Jing Zhang, Weiping Jia
Journal Article
Metformin and metabolic diseases: a focus on hepatic aspects
Juan Zheng,Shih-Lung Woo,Xiang Hu,Rachel Botchlett,Lulu Chen,Yuqing Huo,Chaodong Wu
Journal Article
denitrification system with short-term pyridine exposure: Process capability, inhibition kinetics and metabolic
Journal Article
Water-dispersible nano-pollutions reshape microbial metabolism in type-specific manners: A metabolic
Journal Article
Zinc homeostasis in the metabolic syndrome and diabetes
Xiao Miao, Weixia Sun, Yaowen Fu, Lining Miao, Lu Cai
Journal Article
Low-temperature caproate production, microbial diversity, and metabolic pathway in xylose anaerobic fermentation
Journal Article